ANALISIS EKSPRESI TRANSPORTER ZINK (ZNT-1) SEBAGAI FAKTOR PROGNOSIS ADENOKARSINOMA PROSTAT

Feriandri Utomo✉, Nurjati Chairani Siregar, Ria Kodariah
DOI: https://doi.org/10.22338/mka.v39.i1.p11-20.2016

Abstract

Penurunan kadar Zink (Zn) berkorelasi dengan peningkatan skor Gleason adenokarsinoma prostat, dan rendahnya Caspase-3 (eksekutor apoptosis). Ekspresi ZIP-1 (importer Zn) turun pada adenokarsinoma prostat. Korelasi ZnT-1 (eksporter Zn), ZIP-1 dan Caspase-3 diduga berpotensi menjadi faktor prognosis adenokarsinoma prostat. Penelitian ini bertujuan menganalisis korelasi ekspresi ZnT-1, ZIP-1, Caspase-3 dan skor Gleason adenokarsinoma prostat. Studi retrospektif analitik potong lintang dilakukan pada 14 kasus adenokarsinoma prostat skor Gleason ≤7 dan 16 kasus dengan skor Gleason >7. Ekspresi ZnT-1 dinilai dengan metode imunohistokimia. Analisis tambahan dilakukan untuk melihat korelasi ZnT-1, ZIP-1 dan Caspase-3. Hasil penelitian didapatkan ZnT-1 pada skor Gleason >7 lebih rendah daripada skor Gleason ≤7. ZnT-1 berkorelasi dengan skor Gleason. ZnT-1 berkorelasi dengan ZIP-1 pada skor Gleason >7. ZIP-1 berkorelasi dengan Caspase-3 pada skor Gleason ≤7. ZIP-1 berkorelasi kuat dengan Caspase-3 pada skor Gleason 8. Penelitian ini menyimpulkan rendahnya ekspresi ZnT-1 dan ZIP-1 berpotensi menjadi faktor prognosis adenokarsinoma prostat.

Keywords

ZnT-1; ZIP-1; Caspase-3; adenokarsinoma prostat; skor Gleason

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