Exploring the Link Between Oxidative Stress Reduction and Liver Function Improvement in Jaundiced Rats with Lactococcus lactis D4

Avit Suchitra; Alvarino; Eryati Darwin; Harnavi Harun Harnavi Harun; M. iqbal Rivai; Hannan Khairu Anami; Reza Yuneri Putri; Suci Berlian Hemilton

doi:10.25077/mka.v48.i1.p55-62.2025

Authors

Avit Suchitra Surgery Department, Faculty of Medicine, Universitas Andalas, Jl. Perintis Kemerdekaan No.94, Padang, Indonesia
Alvarino Surgery Department, Faculty of Medicine, Universitas Andalas, Jl. Perintis Kemerdekaan No.94, Padang, Indonesia
Eryati Darwin Departemen Histologi, Fakultas Kedokteran Universitas Andalas, Padang 25163, Indonesia
Harnavi Harun Harnavi Harun Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Andalas, Padang 25163, Indonesia
M. iqbal Rivai Departemen Bedah Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil, Padang 25163, Indonesia
Hannan Khairu Anami Departemen Bedah Fakultas Kedokteran Universitas Andalas, RSUP Dr. M. Djamil, Padang 25163, Indonesia
Reza Yuneri Putri S1 Profesi Dokter, Fakultas Kedokteran Universitas Andalas, Padang, 25163, Indonesia
Suci Berlian Hemilton S1 Profesi Dokter, Fakultas Kedokteran Universitas Andalas, Padang, 25163, Indonesia

DOI:

https://doi.org/10.25077/mka.v48.i1.p55-62.2025

Keywords:

Obstructive jaundice, Lactococcus lactis D4 starter fermented milk, Malondialdehyde, SGOT

Abstract

Objective: To explore the correlation between the reduction of oxidative stress and liver enzyme function in rats with obstructive jaundice, using malondialdehyde (MDA) levels as a biochemical marker, and its impact on serum glutamic oxaloacetic transaminase (SGOT) levels; Method: This experimental study used a post-test only randomized control group design in three groups of Rattus norvegicus strain Wistar rats with an obstructive jaundice model. The rats underwent biliary duct ligation and received Lactococcus lactis D4 starter fermented milk for 7 days. Oxidative stress was assessed by measuring MDA levels and Liver function was assessed by measuring levels of SGOT ; Result:Â The correlation analysis show an r-value of 0.886 revealed that there a very strong positive correlation between MDA and SGOT levels after LLD4 administration; Conclusion: Lactococcus lactis D4 starter fermented milk can improve liver function, indicated by decreased MDA levels and SGOTÂ levels in experimental animals.