The Effect of Mesenchymal Stem Cell Wharton Jelly on Alzheimer’s Rat with Y-Maze Test Method

Sisca Dwi Yarni✉, Hirowati Ali, Djong Hon Tjong
DOI: https://doi.org/10.25077/mka.v44.i2.p112-116.2021

Abstract

Objective: This study aims to examine the y-maze test in alzheimer's rat after giving mesenchymal stem cell wharton jelly. Methods: This study used the y-maze test method to test the cognitive test of rat with the Y arm model. The treatment group consisted of a control, AlCl3, MSC-WJ and a combination of AlCl3 and MSC-WJ. The results obtained were analyzed in the form of a percentage. Results: The results of this study showed that the y-maze test showed that MSC-WJ had a significant effect compared to the AlCl3 control group in the alzheimer’s rat, namely 51.33% and 12.31%. Conclusion: In this study it was concluded that that MSC-WJ has a significant effect on alzheimer’s rat with y maze test.

Keywords: AlCl3; Alzheimer’s; Mesenchymal Stem Cell Wharton Jelly

Keywords

AlCl3; Alzheimer’s; Mesenchymal Stem Cell Wharton Jelly

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References

Zhuo, Y. 2015. Modulating Calcium Signaling by Protein Design and Analysis of Calcium Bindng Proteins. https://scholarworks.gsu.edu/chemistry_diss.

Ru, M and Liu, H. 2018. According to Ru and Liu. Learning and memory processes are very important for an organism's ability to adapt to environmental changes. BioMed Research International. https://doi.org/10.1155/2018/6381932.

Chang, Y. H., Wu, K. C., Liu, H. W., Chu, T. Y dan Ding, D. C. 2018. Human umbilical cord‑derived mesenchymal stem cells reduce monosodium iodoacetate‑induced apoptosis in cartilage. Tzu Chi Medical Journal 2018; 30(2): 71‑80. Doi: 10.4103/tcmj.tcmj_23_18.

Lykhmus, O., Koval, L., Voytenko, L., Uspenska, K., Komisarenko, S., Deryabina, O., Shuvalova, N., Kordium, V., Ustymenko, A., Kyryk, V dan Skok, M. 2019. Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice. Frontiers in Pharmacology, Volume 10, Article 355. Doi: 10.3389/fphar.2019.00355.

Staff, N. P., Jones, D. T dan Singer, W. 2019. Mesenchymal Stromal Cell Therapies for Neurodegenerative Diseases. Mayo Clin Proc. 2019;94(5):892-905.

Pletnikov, M.V and Yocum, J.L. Behavioral Core User Manual. Diakses pada 11 Juli 2020.

Tong, L.M., Fong, H and Huang, Y. 2014. Stem cell therapy for Alzheimer’s disease and related disorders: current status and future perspectives. Experimental & Molecular Medicine (2015) 47, e151; doi:10.1038/emm.2014.124.

Shin, J. Y., H. J. Park, H. N. Kim et al. 2014. Mesenchymal stem cells enhance autophagy and increase β-amyloid clearance in Alzheimer disease models. Autophagy, vol. 10, no. 1, pp. 32–44, 2014.

Yao, P., Zhou, L., et al. 2020. Mesenchymal Stem Cells: A Potential Therapeutic Strategy for Neurodegenerative Diseases. Eur Neurol 2020;83:235–241. DOI: 10.1159/000509268.

Wahl, D., Coogan, S.C.P., Biet, S.M.S., Cabo, R.D. 2017. Cognitive and behavioral evaluation of nutritional interventions in rodent models of brain aging and dementia. Clin Interv Aging. 2017; 12: 1419–1428.



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