Karakteristik morfologi penderita karsinoma payudara dengan reseptor estrogen positif dan negatif berdasarkan duplex ultrasound
Abstract
Tujuan: Penelitian ini bertujuan mengetahui karakteristik morfologi dan vaskularisasi karsinoma payudara dengan reseptor estrogen positif dan negatif berdasarkan ultrasonografi grayscale dan doppler. Metode: Penelitian ini dilakukan di Bagian Radiologi RS Wahidin Sudirohusodo dan RS Pendidikan Universitas Hasanuddin Makassar pada Oktober 2018 sampai dengan Februari 2019. Penelitian ini merupakan jenis penelitian deskriptif dengan metode kajian potong lintang. Analisis data menggunakan statistik melalui uji diagnostik chi-square dan Mann-Whitney. Sampel penelitian sebanyak 40 orang dengan karsinoma payudara. Hasil: Hasil penelitian menunjukkan terdapat perbedaan rata-rata yang signifikan (p<0,05) pada morfologi akustik posterior antara reseptor estrogen positif dan negatif karena akustik posterior shadowing dominan pada reseptor estrogen positif, sedangkan akustik posterior enhancement dominan pada reseptor estrogen negatif. Morfologi akustik posterior ini hanya dapat dinilai dengan menggunakan ultrasonografi grayscale. Simpulan: Terdapat perbedaan yang signifikan pada morfologi akustik posterior dimana akustik posterior shadowing dominan pada reseptor estrogen positif, dan akustik posterior enhancement dominan pada reseptor estrogen negatif.
Keywords
Full Text:
PDFReferences
American Cancer Society. Breast cancer: early detection. 2012. Available from: http://cancer.about.com/od/breastcancer/a/breast_cancer.htm
Ghoncheh M, Pournamdar Z, Salehiniya H. Incidence and Mortality and Epidemiology of Breast Cancer in the World. Asian Pac J Cancer Prev. 2016; 17:43-46.
GLOBOCAN. Cancer Fact Sheets: Breast Cancer. Lyon: International Agency for Research on Cancer; 2012. Available from: http://globocan.iarc.fr/old/FactSheets/cancers/breast-new.asp
Pusat Data dan Informasi Kementerian Kesehatan RI. Infodatin: Stop Kanker. Jakarta: Kementerian Kesehatan RI; 2015. Available from: http://www.depkes.go.id/resources/download/pusdatin/infodatin/infodatin-kanker.pdf
Gupta K, Chandra T, Kumaresan M. Role of Color Doppler for Assessment of Malignancy in Solid Breast Masses: A Prospective Study. International Journal of Anatomy, Radiology and Surgery. 2017; 6(1):RO59-RO65.
Busilacchi P, Draghi F, Preda L, Ferranti C. Has color Doppler a role in the evaluation of mammary lesions?. Journal of Ultrasound. 2012; 15:93-98.
Sohn YM, Han K, Seo M. Immunohistochemical Subtypes of Breast Cancer: Correlation with Clinicopathological and Radiological Factors. Iran J Radiol. 2016; 13(4).
Hon JD, Singh B, Sahin A, Du G, Wang J, Wang VY, et al. Breast cancer molecular subtypes: from TNBC to QNBC. Am J Cancer Res. 2016; 6(9):1864-1872.
Irshad A, Leddy R, Pisano E. Assessing the Role of Ultrasound in Predicting the Biological Behavior of Breast Cancer. AJR. 2013; 200:284-290.
Li Z, Ren M, Tian J. The Differences in Ultrasound and Clinicopathological Features between Basal-Like and Normal-Like Subtypes of Triple Negative Breast Cancer. PLoS ONE. 2015; 10(3):e0114820.
Kim S, Lee HJ, Ko KH. New Doppler imaging technique for assessing angiogenesis in breast tumors: correlation with immunohistochemically analyzed microvessels density. Acta Radiologica. 2018; 1-8.
Shaheen R, Sohail S, Siddiqui KJ. Neovascularity Patterns in Breast Carcinoma: Correlation of Doppler Ultrasound Features with Sonographic Tumour Morphology. Journal of the College of Physicians and Surgeons Pakistan. 2010; 20(3):162-166.
Davoudi Y, Borhani B, Rad MP, Matin N. The Role of Doppler Sonography in Distinguishing Malignant from Benign Breast Lesions. Journal of Medical Ultrasound. 2014; 22:92-95.
Lee SW, Choi HY, Baek SY, Lim SM. Role of color and power Doppler imaging in differentiating between malignant and benign solid breast masses. J Clin Ultrasound 2002;30:459e64.
Choi HY, Kim HY, Baek SY, Kang BG, Lee SW. Significance of Resistive Index in Color Doppler Ultrasonogram: Differentiation Between Benign and Malignant Breast Masses. CLINICAL IMAGING. 2000; 23:284–288.
Sirous M, Sirous R, Nejad FK, Rabeie E, Manzouri M. Evaluation of different aspects of power Doppler sonography in differentiating and prognostication of breast masses. J Res Med Sci. 2015; 20(2):133–139.
