Potensi mikrosfer kombinasi fukoidan dan mirna-200c sebagai inovasi penatalaksanaan kanker payudara kemoresisten
Abstract
Kanker payudara adalah penyakit tidak menular dan juga masalah kesehatan utama di dunia. Berdasarkan data WHO pada 2012, kejadian kanker payudara dilaporkan sebanyak 1,67 juta kasus. Salah satu penyebab morbiditas dan mortalitas tertinggi pada kanker payudara adalah kemoresisten. Tujuan: Untuk menggambarkan potensi kombinasi mikrosfer fukoidan dan miRNA-200c sebagai terapi untuk kanker payudara kemoresisten. Metode: Dilakukan telaah pada literatur tervalidasi seperti jurnal dan website. Kata kunci yang digunakan yaitu “Fucoidan” dan “Chemoresistant breast cancer and miRNA-200c” pada search engine www.pubmed.com dan scholar.google.com. Dari 77 jurnal yang ditelaah, 55 jurnal ditemukan sesuai dengan topik bahasan dan digunakan sebagai referensi karya ini. Hasil: Kombinasi mikrosfer ini akan membawa sel target spesifik dalam kemoresistensi kanker payudara. Fukoidan sebagai agen pro-apoptosis mempengaruhi banyak sel target (multi-target) untuk menginduksi apoptosis. Sementara itu, ekspresi miRNA-200c menginduksi Mesenchymal Epithelial Transition (MET) dengan menghambat ZEB1, ZEB2 dan TGF-β2 sebagai anti-metastasis pada chemoresistance kanker payudara. Simpulan: Kombinasi mikrosfer fukoidan dan miRNA-200c memiliki potensi yang menjanjikan sebagai pengobatan baru untuk kemoresistensi kanker payudara, karena sifat proapoptotik dan anti metastasis yang manjur. Namun, belum ada penelitian yang mengevaluasi kombinasi ini. Jadi studi lebih lanjut diperlukan untuk mengkonfirmasi potensi sebenarnya dari kombinasi mikrosfer fukoidan dan miRNA-200c.
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