PERBANDINGAN PROGNOSIS SUBTIPE MOLEKULER KANKER PAYUDARA ANTARA PASIEN KANKER PAYUDARA WANITA USIA MUDA DAN TUA DI RSUP DR. M. DJAMIL PADANG

Irwan Irwan, Azamris Azamris, Hafni Bachtiar

Abstract

Abstrak
Penelitian sebelumnya menunjukkan bahwa subtipe molekuler kanker payudara memiliki perbedaan distribusi dan efek prognostik antara usia muda dan tua, sedangkan data lokal maupun nasional tidak ada penulis temukan. Metode : Penelitian komparatif dengan metode cross sectional. Dilakukan bulan Januari – April 2015, sampel 96 penderita kanker payudara wanita usia ≤ 40 tahun dan > 40 tahun yang tercatat di rekam medis dan registrasi kanker payudara dari tahun 2012 – 2014. Hasil : Kejadian kanker payudara wanita usia muda di RSUP dr. M. Djamil Padang selama 3 tahun (2012-2014) yaitu 27,1% dan usia tua 72,9%. Analisa bivariat tidak menunjukkan hubungan yang signifikan antara berbagai karakteristik tumor dengan kejadian residif dan meninggal pada usia muda. Sedangkan pada usia tua, terdapat hubungan yang signifikan antara ukuran tumor dan metastasis terhadap kejadian residif dan meninggal. Kesimpulan : Ada perbedaan karakteristik dan gambaran subtipe molekuler kanker payudara antara usia muda dan tua, usia muda tumor cenderung berukuran besar, kelenjar getah bening positif, adanya invasi limfovaskuler, grade tumor tinggi, indeks proliferasi Ki67 tinggi serta reseptor hormon negatif. Terdapat kecenderungan perbedaan prognosis kanker payudara wanita antara usia muda dan tua berdasarkan subtipe molekuler namun tidak bermakna secara statistik.

Abstract
Previous study showed that molecular subtypes of breast cancer have different distribution and prognostic effect between the young and adult, whereas it cannot found in the local and national data. Method : Comparative research with cross sectional design. Held in January-April 2015, Ninety six samples of breast cancer women with age ≤ 40 years old and > 40 years old that has been recorded in medical records and breast cancer registration from year 2012-2014. Result : Breast cancer that happened to young women at General Hospital dr. M. Djamil Padang for 3 years (2012-2014) are 27,1% and the adult are 72,9%. In bivariat analysis, there are not relationship between characteristics of tumor with recurrent and death while in the adult women breast cancer, tumor size and metastases have relation with recurrent and death that are significant statistically. Conclusion : There are different characteristics and description of breast cancer molecular subtype between young and adult women, young ages are tend to have big tumor, lymph node positive, lymphovascular invasion, high grade tumor, proliferation index Ki67 high and negative hormone receptor. There are differences tendency of prognosis women breast cancer between the young and adult based on molecular subtype but statistically, the relationship is not significant.

Keywords

usia; subtipe molekuler kanker payudara; prognosis; age; breast cancer molecular subtype; prognosis

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