Sindrom Guillain-barre dengan Multisystem Inflammatory Syndrome in Children (MIS-C)
Abstract
Sindrom Guillain-Barre (SGB) adalah penyakit autoimun yang menyerang saraf tepi, dapat dipicu oleh infeksi yang baru terjadi, dan mengenai segala usia. Gejala SGB berupa kelemahan progresif yang dimulai dari anggota gerak hingga otot kranial dan pernapasan, menyebabkan kelumpuhan total, kegagalan pernapasan, bahkan kematian. Multisystem Inflammatory Syndrome in Children (MIS-C) adalah kumpulan gejala inflamasi multisistem berkaitan dengan infeksi COVID-19, yang dapat menyebabkan kegagalan organ multipel. MIS-C menyebabkan beberapa gejala neurologis pada anak dan remaja, termasuk sindrom Guillain-Barre (SGB). Pada laporan kasus ini kami membahas mengenai anak laki-laki berusia 1 tahun yang didiagnosis Sindrom Guillain-Barre dengan MIS-C. Pasien mendapatkan terapi IVIG, obat-obatan, dan terpasang ventilator. Pasien dirawat di ruang intensive anak dengan lama rawatan selama 18 hari. Kondisi pasien telah mengalami perbaikan dan pasien diperbolehkan untuk rawat jalan serta pemantauan ke poliklinik anak.
Kata kunci: Sindrom Guillain-Barre; MIS-C
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Jiang L, Tang K, Levin M, Irfan O, Morris SK, Wilson K, et al. COVID-19 and multisystem inflammatory syndrome in children and adolescents. 2020;20:276–88.
Kwak JH, Lee SY, Choi JW. Clinical features, diagnosis, and outcomes of multisystem inflammatory syndrome in children associated with coronavirus disease 2019. Korean J Pediatr. 2021;64:68–75.
Yasuhara J, Watanabe K, Takagi H, Sumitomo N, Kuno T. COVID-19 and multisystem inflammatory syndrome in children: A systematic review and meta-analysis. Pediatr Pulmonol. 2021;56:837–48.
Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020;383:334–46.
Larovere KL, Riggs BJ, Poussaint TY, Young CC, Newhams MM, Maamari M, et al. Neurologic Involvement in Children and Adolescents Hospitalized in the United States for COVID-19 or Multisystem Inflammatory Syndrome. JAMA Neurol. 2021;78:536–47.
Gupta Dch S, Chopra Md N, Singh Md A, Gera R, Chellani Md H, Pandey Phd R, et al. Unusual Clinical Manifestations and Outcome of Multisystem Inflammatory Syndrome in Children (MIS-C) in a Tertiary Care Hospital of North India. J Trop Pediatr. 2021;67:1–9.
Ahmed M, Advani S, Moreira A, Zoretic S, Martinez J, Chorath K, et al. Multisystem inflammatory syndrome in children: A systematic review. EClinicalMedicine [Internet]. 2020;26:100527. Available from: https://doi.org/10.1016/j.eclinm.2020.100527
Kaushik S, Ahluwalia N, Gangadharan S, Esperenza M, Murthy R, Ofori- Amanfo G, et al. ECMO support in SARS-CoV2 multisystem inflammatory syndrome in children in a child. Perfus (United Kingdom). 2021;36:524–8.
Mehra B, Aggarwal V, Kumar P, Kundal M, Gupta D, Kumar A, et al. Covid-19 associated severe multisystem inflammatory syndrome in children with encephalopathy and neuropathy in an adolescent girl with the successful outcome: An unusual presentation. Indian J Crit Care Med. 2020;24:1276–8.
Waseda Y, Johkoh T, Prosch H, Nemec S, Saeki K, Watanabe S, et al. MORH-D-21-00016 Received : 15-Jan-2021 ; Accepted : 27-Apr-2021 Original Article © Japan College of Rheumatology 2021 . All rights reserved . For permissions , please e-mail : journals.permissions@oup.com. 2021;5:1–24.
Willison HJ, Jacobs BC, van Doorn PA. Guillain-Barré syndrome. Lancet. 2016;388:717–27.
Estrade S, Guiomard C, Fabry V, Baudou E, Cances C, Chaix Y, et al. Prognostic factors for the sequelae and severity of Guillain-Barré syndrome in children. Muscle and Nerve. 2019;60:716–23.
CDC. Guillain-Barré Syndrome [Internet]. 2019. p. 1–2. Available from: https://www.cdc.gov/campylobacter/guillain-barre.html
Papri N, Islam Z, Leonhard SE, Mohammad QD, Endtz HP, Jacobs BC. Guillain–Barré syndrome in low-income and middle-income countries: challenges and prospects. Nat Rev Neurol [Internet]. 2021;17:285–96. Available from: http://dx.doi.org/10.1038/s41582-021-00467-y
Momen AA, Shakurnia A. The Epidemiology of Guillain-Barré Syndrome in Children under 15 Years Old in Southwest Iran. Biomed Hub. 2017;2:1– 8.
Asiri S, Altwaijri WA, Ba-Armah D, Rumayyan A Al, Alrifai MT, Salam M, et al. Prevalence and outcomes of guillain-barré syndrome among pediatrics in Saudi Arabia: A 10-year retrospective study. Neuropsychiatr Dis Treat. 2019;15:627–35.
Dufort EM, Koumans EH, Chow EJ, Rosenthal EM, Muse A, Rowlands J, et al. Multisystem Inflammatory Syndrome in Children in New York State. N Engl J Med. 2020;383:347–58.
O’Loughlin L, Alvarez Toledo N, Budrie L, Waechter R, Rayner J. A Systematic Review of Severe Neurological Manifestations in Pediatric Patients with Coexisting SARS-CoV-2 Infection. Neurol Int. 2021;13:410– 27.
Rothan HA, Byrareddy SN. The potential threat of multisystem inflammatory syndrome in children during the COVID-19 pandemic. Pediatr Allergy Immunol. 2021;32:17–22.
Salman H, Aslan N, Akkuzu E, Keskin M, Training M, Hospital IS, et al. MORH-D-21-00238 Received : 16-Apr-2021 ; Accepted : 14-Jul-2021 Original Article © Japan College of Rheumatology 2021 . All rights reserved . For permissions , please e-mail : 2021;
Schober ME, Robertson CL, Wainwright MS, Roa JD, Fink EL. COVID- 19 and the Pediatric Nervous System: Global Collaboration to Meet a Global Need. Neurocrit Care [Internet]. 2021; Available from: https://doi.org/10.1007/s12028-021-01269-2
Losy J. SARS-CoV-2 Infection: Symptoms of the Nervous System and Implications for Therapy in Neurological Disorders. Neurol Ther [Internet]. 2021;10:31–42. Available from: https://doi.org/10.1007/s40120-020- 00225-0
Apellidoa N. Clinical profile and immediate outcome of Multisystem Inflammatory Syndrome in Children (MIS-C) associated with Covid-19: a multicentric study. Rev Latinoam Metal y Mater. 2020;39:156–61.
Shenker J, Trogen B, Schroeder L, Ratner AJ, Kahn P. Multisystem Inflammatory Syndrome in Children Associated with Status Epilepticus. J Pediatr [Internet]. 2020;227:300–1. Available from: https://doi.org/10.1016/j.jpeds.2020.07.062
Sa M, Mirza L, Carter M, Carlton Jones L, Gowda V, Handforth J, et al. Systemic Inflammation Is Associated With Neurologic Involvement in Pediatric Inflammatory Multisystem Syndrome Associated With SARS- CoV-2. Neurol Neuroimmunol neuroinflammation. 2021;8.
Abu-Rumeileh S, Abdelhak A, Foschi M, Tumani H, Otto M. Guillain– Barré syndrome spectrum associated with COVID-19: an up-to-date systematic review of 73 cases [Internet]. Vol. 268, Journal of Neurology. Springer Berlin Heidelberg; 2021. 1133–1170 p.
Carrillo-Larco RM, Altez-Fernandez C, Ravaglia S, Vizcarra JA. COVID- 19 and Guillain-Barre Syndrome: a systematic review of case reports [version 1; peer review: awaiting peer review]. Wellcome Open Res [Internet]. 2020;1–9. Available from: https://search.proquest.com/docview/2407843982?accountid=26724 http://sfx.library.cdc.gov/cdc/?url_ver=Z39.88- 2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&genre=article&sid=ProQProQ%3Ahealthcompleteshell&atitle=COVID-19+and+Guillain- Barre+Syndrome%3A+a+
Simões JLB, Bagatini MD. Purinergic Signaling of ATP in COVID-19 Associated Guillain-Barré Syndrome. J Neuroimmune Pharmacol. 2021;16:48–58.
Dalakas MC. Guillain-Barré syndrome: The first documented COVID-19- triggered autoimmune neurologic disease: More to come with myositis in the offing. Neurol Neuroimmunol neuroinflammation. 2020;7.
Rodríguez Y, Rojas M, Pacheco Y, Acosta-Ampudia Y, Ramírez-Santana C, Monsalve DM, et al. Guillain–Barré syndrome, transverse myelitis and infectious diseases. Cell Mol Immunol. 2018;15:547–62.
Islam Z, Papri N, Ara G, Ishaque T, Alam AU, Jahan I, et al. Risk factors for respiratory failure in Guillain-Barré syndrome in Bangladesh: a prospective study. Ann Clin Transl Neurol. 2019;6:324–32.
Ediboğlu Ö, Ataman S, Kirakli C. Characteristics of influenza pneumonia patients admitted to the ICU due to hypoxemic respiratory failure. Tuberk Toraks. 2018;66:52–6.
Elias MD, McCrindle BW, Larios G, Choueiter NF, Dahdah N, Harahsheh AS, et al. Management of Multisystem Inflammatory Syndrome in Children Associated With COVID-19: A Survey From the International Kawasaki Disease Registry. CJC Open [Internet]. 2020;2:632–40. Available from: https://doi.org/10.1016/j.cjco.2020.09.004
Feketea G, Vlacha V, Bocsan IC, Vassilopoulou E, Stanciu LA, Zdrenghea M. Vitamin D in Corona Virus Disease 2019 (COVID-19) Related Multisystem Inflammatory Syndrome in Children (MIS-C). Front Immunol. 2021;12:1–7.
Darren A, Osman M, Masilamani K, Habib Ali S, Kanthimathinathan HK, Chikermane A, et al. Vitamin D status of children with Paediatric Inflammatory Multisystem Syndrome Temporally associated with Severe acute respiratory syndrome coronavirus 2 (PIMS-TS). Br J Nutr. 2021;1–8.
Abrams JY, Oster ME, Godfred-Cato SE, Bryant B, Datta SD, Campbell AP, et al. Factors linked to severe outcomes in multisystem inflammatory syndrome in children (MIS-C) in the USA: a retrospective surveillance study. Lancet Child Adolesc Heal [Internet]. 2021;5:323–31
Radia T, Williams N, Agrawal P, Harman K, Weale J, Cook J, et al. Multi- system inflammatory syndrome in children & adolescents (MIS-C): A systematic review of clinical features and presentation. Paediatr Respir Rev [Internet]. 2021;38:51–7. Available from: https://doi.org/10.1016/j.prrv.2020.08.001