Efek Protektif Ekstrak Etanol Umbi Bawang Dayak (Eleutherine bulbosa (Mill.) Urb.) terhadap Gambaran Histopatologi pada Sel Tumor Payudara Tikus Putih (Rattus norvegicus) Betina Galur Sprague Dawley Diinduksi 7,12 Dimethylbenz(α)Anthracene

Abstract

Objective: To determine the effect of ethanol extract of dayak onion bulb on histology of mammary tumor cells in female Sprague Dawley rats strains that were induced by 7,12 dimethylbenz(α)anthracene (DMBA). Methods: The design of this study was a post-test only control group. DMBA (20 mg/kgBW) was given peroral twice a week for five weeks. In this research 30 female Sprague-Dawley rats  were used and divided into 6 groups. Normal group weren’t treated DMBA; negative control group were treated DMBA and DMSO 5%; positive control group were treated DMBA and tamoxifen; treatment I group were treated DMBA and extract 180 mg/kgBW; treatment II group were treated DMBA and extract 360 mg/kgBW; and  treatment III group were treated DMBA and extract 720 mg/kgBW. Results: There was significant difference between treatment I and negative control group (p=0,015); treatment II and negative control group (p=0,011); treatment III and negative control group (p=0,015). Conclusion: Ethanol extract of dayak onion bulb  have an effect on histology of mammary tumors in female Sprague Dawley rats that were induced by 7,12 dimethylbenz(α)anthracene (DMBA).

Keywords: Eleutherine bulbosa; Anti-cancer; Histopathology; Mammary tumor; 7,12 Dimethylbenz(α)anthracene