PERAN C-FOS SEBAGAI AGEN PROLIFERASI DAN PRO-APOPTOSIS SEBAGAI STRATEGI PENGEMBANGAN PENGOBATAN KANKER

Aisyah Elliyanti

Abstract

Analisis profil molekuler telah memberikan pengertian lebih dalam berkenaan dengan kompleksitas penyakit kanker di tingkat molekuler serta membuka potensi pengunaannya untuk mempelajari jalur onkogenik, hubungan jalur keganasan  dengan sensitivitas terhadap terapi yang memberikan potensi yang besar sebagai petunjuk pengunaan terapi target. C-Fos merupakan proto-onkogen, berikatan dengan Jun membentuk komplek faktor transkripsi  activating protein 1 (AP-1). Sebagai anggota dari AP-1, c-Fos memainkan peran merespon transduksi sinyal proliferasi dan diferensiasi sel yang menyebabkan pertumbuhan sel yang invasif. Sebaliknya laporan penelitian lainnya membuktikan bahwa c-Fos juga memiliki peran sebagai tumor supresor dengan keterlibatannya pada proses apoptosis. Mekanisme molekuler yang jelas tentang keterlibatan c-Fos baik sebagai tumor modulator proliferasi sel maupun supresor  pertumbuhan tumor masih belum jelas. Penelitian lebih lanjut keterlibatan c-Fos di tingkat molekuler sangat penting untuk membuka jalan bagi target baru terapi kanker maupun sebagai marker prognostik penyakit kanker.

Keywords

c-Fos; proliferasi; pro-apoptosis; terapi target

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References

Jimeno A, Kulesza P, Kincaid E, Bouaroud N, Chan A, Forastiere A, et al. Cfos Assesment as A Marker of Anti-epidermal Growth Factor Receptor Effect. Cancer Res. 2006; 66:2385-2390

Jurado, J. Fuentes-Almagro CA, Prieto-Alamo M, Pueyo C. Alternative Splicing of c-Fos Pre-mRNA: Contribution of The Rates of Synthesis and Degradation to The Copy Number of Each Transcript Isoform and Detection of Truncated c-Fos Immunoreactive Species. BMC Molecular Biology. 2007; 8:83

Milde-Langosch K, Roder H, Andritzky B, Aslan B, Hemminger G, Brinkmann A, dkk. The Role of Ap-1 Transcription Factors c-Fos, Fos B, Fra-1 and Fra-2 in Invasion Process of Mamary Carcinomas. Breast Cancer Research and Treatment. 2004; 86:139-152

Lu C, S Q, DuPre E, Kim H, Hilsenbeck S, Brown PH. c-Fos is Critical for MCF7 Breast Cancer Cell Growth. Oncogene. 2005; 24:6516-6524

Mahner S, Baasch C, Schwarz j, Hein S, Wolber L, Midle-langosch K. C-fos Expression is a Molecular Predictor of Progression and Survival in epitelial Ovarian Carcinoma.British Journal of Cancer. 2008; 99:1269-1275

Appierto V, Villani MG, Cavadin E, Lotan R, Vinson C, Formelli F. Involvement of c-Fos in Fenretinide-Induced Apoptosis in Human Ovarian Carcinoma Cells. Cell Death and Differentiation. 2004; 11-270-279

Dahlman-Wright K, Qiao Y, Jonsson P, Gustafsson A, Williams C, Zhao C. Interplay Between AP-1 and Estrogen Receptor α in Regulating Gene Expression and Proliferation Networks in Breast Cancer Cells. Carcinogenesis. 2012; 33:1684-1691

Milde-Langosh K, Bamberger CM, Rieck G, Grund D, Hemminger G, Muller V, Loning T. Expression and Prognostic Relevance of Activated Extracellular-Regulated Kinase (ERK1/2) in Breast Cancer. British J of Cancer. 2005; 92:2206-2215.

Jin SP, Kim JH, Kim MA, Yang H, Lee HE, Lee HS, Kim WH. Prognostic Significance of Loss of c-Fos Protein in Gastric Carcinoma.Pathology Oncology Research. 2007; 13:284-289.

Yuan Z, Gong S, Luo J, Zheng Z, Song B, Ma S, dkk. Opposing Roles for ATF2 and c-Fos in c-Jun-Mediated Neuronal Apoptosis. Molecular and Cellular Biology. 2009; 29:2431-2442

Kharman-Biz A, Gao H, Ghiasvand R, Zhao C, Zendehdel K, Dalman-Wright K. Expression of Activator Protein-1 (AP-1) Family Members in Breast Cancer. BMC Cancer. 2013; 13:441

Wagstaff SC, Bowler WB, Gallagher JA, Hipskind RA. Extracellular ATP Activites Multiple Signalling Pathways and Potentiates Growth Factor-Induced c-fos Gene Expression in MCF-7 Breast Cancer Cells.Carcinogenesis. 2000; 21:2175-2181

Kosigirim. 2007. MAPKpathway melalui http://en.wikipedia.org/wiki/File:MAPKpathway.jpg [02/12/2014]

Ouadid-Ahidouch H, Roudbaraki M, Delcourt P, Ahidouch A, Joury N, Prevarskaya N. Functional dan Molecular Identification of Intermediate-Conductance Ca2+ -activated K+ Channels in Breast Cancer Cell: Association With Cell Cycle Progression. AJP-Cell Physiol. 2004; 287:c125-c134

White N, Burnstock. P2 Receptors and Cancer. Trends in Pharmacological Science. 2006; 27:211-217

Sun D, Junger WG, Yuan C, Zhang W, Bao Y, Qin D, et all. Shockwaves Induce Osteogenic Differentiation of Human Mesenchymal Steam Cells Through ATP Release and Activation of P2X7 Receptors. Stem Cells. 2013; 31:1170:1180

Graves ML, Zhou L, MacDonald G, Mueller CR, Roskelley CD. Regulation of the BRCA1 Promoter in Ovarium Surface Epitelial Cells and Ovarian Carcinoma Cells. FEBS Letters. 2007; 81:1825-1833

Holliday DL, Speirs V. Choosing The Right Cell Line for Breast Cancer Research.Breast Cancer Research. BioMed Central. 2011; 13:215

Pusztai L, Mazouni C, Anderson K, Wu Y, Symmans WF. Molecular Classification of Breast Cancer: Limitation and Potential. The Oncologist. 2006; 11:868-877

Bland KI, Konstadoulakis MM, Vezeridis MP, Wanebo HJ. Oncogene Protein Co-Expression (Value of Ha-ras, c-myc, c-fos, and p53 as prognostic Discriminants for Breast Carcinoma). Annals of Surgery. 1995; 221:706-720

Guller M, Toualbi-Abed K, Legrand A, Michel L, Mauviel A, Bernuau D, dkk. C-Fos Overexpression Increase The Proliferation of Human Hepatocytes by Stabilizing Nuclear Cyclin D1. World J Gastroenterol. 2008; 7:6339-6346

Volm M, Koomagi R, Mattern J, Efferth T. Expression Profile og Genes in Non-Smal Cell Lung Carcinomas From Long-Term Surviving Patients. Clinical Cancer research. 2002; 8:1843-1848

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