PERAN C-FOS SEBAGAI AGEN PROLIFERASI DAN PRO-APOPTOSIS SEBAGAI STRATEGI PENGEMBANGAN PENGOBATAN KANKER

Aisyah Elliyanti✉
DOI: https://doi.org/10.22338/mka.v39.i2.p73-78.2016

Abstract

Analisis profil molekuler telah memberikan pengertian lebih dalam berkenaan dengan kompleksitas penyakit kanker di tingkat molekuler serta membuka potensi pengunaannya untuk mempelajari jalur onkogenik, hubungan jalur keganasan  dengan sensitivitas terhadap terapi yang memberikan potensi yang besar sebagai petunjuk pengunaan terapi target. C-Fos merupakan proto-onkogen, berikatan dengan Jun membentuk komplek faktor transkripsi  activating protein 1 (AP-1). Sebagai anggota dari AP-1, c-Fos memainkan peran merespon transduksi sinyal proliferasi dan diferensiasi sel yang menyebabkan pertumbuhan sel yang invasif. Sebaliknya laporan penelitian lainnya membuktikan bahwa c-Fos juga memiliki peran sebagai tumor supresor dengan keterlibatannya pada proses apoptosis. Mekanisme molekuler yang jelas tentang keterlibatan c-Fos baik sebagai tumor modulator proliferasi sel maupun supresor  pertumbuhan tumor masih belum jelas. Penelitian lebih lanjut keterlibatan c-Fos di tingkat molekuler sangat penting untuk membuka jalan bagi target baru terapi kanker maupun sebagai marker prognostik penyakit kanker.

Keywords

c-Fos; proliferasi; pro-apoptosis; terapi target

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